Association of Lp-PLA2 Mass and Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients

Yan Wang; Jin Zhang; Yuesheng Qian; Xiaofeng Tang; Huawei Ling; Kemin Chen; Pingjin Gao; Dingliang Zhu

doi:10.1371/journal.pone.0130473

Association of Lp-PLA2 Mass and Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients

PLoS One. 2015 Jun 22;10(6):e0130473. doi: 10.1371/journal.pone.0130473. eCollection 2015.

Authors

Yan Wang¹, Jin Zhang¹, Yuesheng Qian¹, Xiaofeng Tang¹, Huawei Ling², Kemin Chen², Pingjin Gao¹, Dingliang Zhu¹

Affiliations

¹ Research Center for Hypertension Management and Prevention in Community, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
² Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Abstract

Background and purpose: Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians, whereas whites tend to have more extracranial lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been associated with ischemic stroke by a large amount of work. However, there are few studies focusing on the relationship of Lp-PLA2 and asymptomatic ICAS or extracranial arterial stenosis (ECAS). Wehereby sought to explore the relationship of Lp-PLA2 and ICAS, ECAS and concurrent stenosis in stroke-free hypertensive patients in Chinese population.

Methods: All the subjects were evaluated for the presence and severity of ICAS and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. Lp-PLA2 mass was measured by enzyme linked immunoassay. The association of Lp-PLA2 and vascular stenosis was analyzed through multivariate logistic regression.

Results: Among 414 participants, 163 (39.4%) had no ICAS or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had ICAS only and 77 (18.6%) had concurrent extraintracranial stenosis. Lp-PLA2 mass was significantly associated with isolated ICAS (OR: 2.3; 95% CI: 1.14-4.64), and concurrent stenosis (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). Lp-PLA2 mass was also associated with moderate to severe ICAS no matter how was the ECAS. Moreover, patients with higher Lp-PLA2 mass showed more sever ICAS and had more intracranial arterial lesions.

Conclusion: This study revealed the association of Lp-PLA2 mass with ICAS in stroke-free hypertensive patients in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of Lp-PLA2 on the asymptomatic ICAS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

1-Alkyl-2-acetylglycerophosphocholine Esterase / blood*
Aged
Biomarkers / blood
Constriction, Pathologic / blood
Constriction, Pathologic / complications
Constriction, Pathologic / diagnostic imaging
Female
Humans
Hypertension / blood*
Hypertension / complications
Hypertension / diagnostic imaging
Intracranial Arterial Diseases / blood*
Intracranial Arterial Diseases / complications
Intracranial Arterial Diseases / diagnostic imaging
Male
Middle Aged
Radiography

Substances

Biomarkers
1-Alkyl-2-acetylglycerophosphocholine Esterase

Grants and funding

This project was supported by grants from the National Key Program for Basic Research (2009CB521905), National Natural Science Foundation of China (81000037 and 81370205), National High Technology Research and Development Program (2006AA02Z179), and Shanghai Hospital Development Center Foundation (SHDC12012304). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.